I was seeing the same issue, the debugger jumping to the disassembly window, and the disabled "operate by instruction" switch. I am using Qt v4.7.3 with Creator v2.2.1 on Windows XP Sp3. I completely uninstalled both, cleaned my registry, and reinstalled. I also deleted the .user file so that it would be regenerated. This enabled the operate by instruction switch, but it was switching between the disassembly window and what looks like code from a referenced library, not the actual breakpoint I set in my code. Next thing I tried was to copy my project to a new location, and change the "Projects" settings in Qt Creator so that it would build to the build folder in the new location. I also deleted the .user file so that it would be regenerated. This fixed everything, the breakpoints and the switch, but I have to use the project in its new location, the project in the old location is still broken. I did a complete file comparison using Araxis Merge between the two project folders. I am mystified by what I found. The only difference throughout all of the files in the folders is the build path. Now, I can't say for sure sure if the binary files are actually being compared. I searched my registry and could not find anything obvious. I believe the issue was originally caused when I built from two different locations into the same build folder. I believe it may be related to the following Qt Creator bug: https://bugreports.qt.nokia.com/brow...REATORBUG-2104
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